Social relationships are both adaptive and crucial for survival, yet in light of the current pandemic we have limited means of fulfilling this biological need. Indeed, evidence suggests social isolation and loneliness were prevalent prior to the pandemic and may be exacerbated. Social connections have powerful influences on our wellbeing, health and longevity and lacking social connection qualifies as a risk factor for premature mortality. Growing evidence also points to the short-term effects on biomarkers of health and health relevant behaviors, guiding understanding of both the causal mechanisms by which social connection influences physical health and the ways in which this influence can inform potential intervention strategies. The current pandemic has shown us how integral social contact is to every aspect of our lives, and thus each of these sectors can play an important role in solutions.