Implementation of Pharmacogenomics into Clinical Care
TCF Bank Stadium
University of Minnesota
Pharmacogenomics (PGx) is the science of how an individual’s genetic background impacts response to medications. The field has left the research realm and has emerged as an important tool for clinical care. There is also a growing interest by consumers in PGx testing, fueled by direct-to-consumer availability of testing. Many academic and large private health systems have implemented PGx and now smaller non-academic centers are beginning or considering implementation into routine practice. Having a clear understanding of the current scientific evidence, emerging evidence, and knowledge of successful implementation pathways and examples are critical for successful launch.
This two-day conference will provide PGx implementation education on a range of topics through lectures and smaller group breakout sessions. The first day will focus on general knowledge that supports drug-gene pairs commonly implemented in practice, and data emerging for new drug-gene pairs that may be in the pipeline for implementation. The efforts by CPIC in authoring guidelines and a behind-the-scenes look at the CPIC scientific review process will be presented. Strategies to return PGx results to patients, how to use PGx information in the absence of a guideline or in the setting of a simultaneous drug-drug interaction will be covered. The second day will focus on PGx best practices and strategies for successful implementation. Four well-established programs will present their PGx programs and share the successes and pitfalls they encountered during the development of their programs. Best practices in creating a multidisciplinary PGx team, selecting a laboratory for testing, how to use online tools such as PharmVar, cost effectiveness, genetic variants in minority populations, how PGx improves quality of care and safety, and PGx clinical decision support will be presented.