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COVID-19 Research at the University of Minnesota

Our portfolio of CO:VID (Collaborative Outcomes: Visionary Innovation & Discovery) grants support COVID-19 research and clinical projects. The research grants program is open for University of Minnesota faculty to catalyze and energize small-scale research projects designed to address and mitigate the COVID-19 virus and its associated risks. The clinical grants program support small-scale clinical projects in response to the COVID-19 pandemic and are targeted to proposals that explore new ways to diagnose and treat the SARS-CoV-2 virus.
 

Funded CO:VID Grants as of 7/29:

  1. Develop and Test a 3D Printed Ventilator Manifold and a Low Cost Ventilator that Would Meet the Current Guidelines in a Surge Crisis
    PI: Roy J. Cho, MD, MHA, Medical School
  2. Impact of the Novel Coronavirus COVID-19 on the Care and Outcomes of Patients with Cancer: A Cohort Study
    PI: Amit Kulkarni, MD, Medical School
  3. Parameter Values for COVID-19 in the United States
    PI: Amy Kinsley, DVM, PhD, College of Veterinary Medicine
  4. Perceptions of COVID-19 and Health
    PI: Rachel Vogel, PhD, Medical School
  5. How Much Social Distance is Enough? Family Preparedness and Responses to Non-Pharmacologic Interventions During the COVID-19 Pandemic
    PIs: Gillian Tarr, PhD, CPH & Marizen Ramirez, PhD, MPH, School of Public Health
  6.  Biophysical Modeling of COVID-19 Clinical Trials
    PI: David Odde, PhD, College of Science and Engineering
  7. Social Media as an Emergency Response System: COVID-19 and Our Unprecedented Need for Information and Social Engagement
    PI: Jude Mikal, PhD, School of Public Health
  8. Identifying SARS-CoV-2 Vulnerabilities
    PI: Alon Herschhorn, PhD, Medical School
  9. Regulation for the SARS-CoV-2 Receptor ACE2 by ADAM17
    PI: Bruce Walcheck, PhD, College of Veterinary Medicine
  10. Impact of Virtual Rounding for Patients with COVID-19 for Patient Satisfaction and Provider Safety
    PI: Michael Usher, MD, PhD, Medical School
  11. Novel Therapeutics Directed to COVID-19 RNA Targets
    PI: Kathleen Boris-Lawrie, PhD, College of Veterinary Medicine
  12. Rapid, Field Deployable COVID-19 Testing
    PI: Mark Osborn, PhD, Medical School
  13. Convenient and Sensitive Detection of SARS-CoV-2 Infection by ELISA
    PI: Yuying Liang, PhD, College of Veterinary Medicine
  14. Development of a Low-Cost, Scalable Mechanical Ventilator
    PI: Stephen Richardson, MD, Medical School
  15. Development of Vaccines Against COVID-19
    PI: Hinh Ly, PhD, College of Veterinary Medicine
  16. Linkage of Cancer Biobanks and Registries to Understand COVID-19 Pathogenesis
    PI: Heather Nelson, PhD, MPH, Masonic Cancer Center
  17. Immune-Signature to Evaluate COVID-19-Related Liver Injury and Outcomes
    PIs: Jose Debes, MD, MS &  Thomas Leventhal, MD, Medical School
  18. Independent Pressure Control for Multi-Patient Ventilators
    PI: James D. Van de Ven, PhD, Mechanical Engineering
  19. Reducing Particles Aerosolized by NIPPV Support Devices to Offload Ventilation and ICU Bed Usage
    PI: Hai-Thien Phu, MD, Medical School
  20. Minnesota Families: Understanding How to Best Tailor Our Public Health Response to Support Families During COVID-19
    PI: Katie Loth, PhD, MPH, Medical School
  21. SARS-CoV-2 in Tears
    PI: Hossein Nazari, MD, Medical School
  22. Point of Care Testing of SARS-CoV-2 by Using Smart Phone-Based Fluorescence Imaging
    PI: Louis Mansky, PhD, Institute for Molecular Virology
  23. Developing Portable Magnetic Bio-assay Platforms for the Detection of SARS-COV-2
    PIs: Jian-Ping Wang, PhD & Maxim Cheeran, MVSc, PhD, College of Science and Engineering
  24. Study to Elucidate the Mechanisms of Inhibiting SARS-CoV-2 (COVID19) Viral Entry into the Lung Epithelial Cells
    PI: Hemant Mishra, PhD, College of Veterinary Medicine
  25. Leveraging Network Science to Help Decision Makers and the Public Understand the Effects of Implementation and Relaxation of Social Distancing Measures on COVID-19 Viral Spread
    PI: Meggan Craft, PhD, College of Veterinary Medicine
  26. COVID-19 Virtual Care
    PI: Pita Adam, MD, MSPH, Medical School
  27. Early Detection of COVID-19 Using Unobtrusive, Wearable Sensor Data
    PI: Deniz S. Ones, PhD, College of Liberal Arts & Michael Cullen, Medical School
  28. Leveraging Virtual Reality to Improve Compliance with Social Distancing
    PI: Evan Suma Rosenberg, PhD, Computer Science & Engineering
  29. Non-Thermal Cold Plasma Technology for Decontamination of Personal Protective Equipment (Face Masks and Face Shields) from SARS-COV2
    PI: Sagar M. Goyal, PhD, College of Veterinary Medicine
  30. Magnesium Supplementation for Preventing Sudden Cardiac Death by COVID-19 Viroporins in Patients with Pre-Existing Hypertension
    PI: Jin O-Uchi, MD, PhD, FAHA, FCVS, Medical School
  31. Optimizing Communication Strategies for Reaching At-Risk Somali, Latino/a/x, and Hmong Elders with Timely COVID19 Information
    PIs: Michele Allen, MD, MS & Maiyia Kasouaher, PhD, Medical School
  32. Analyzing Aerosol Generation with Various Oxygen Delivery Methods
    PIs: Nate Gaeckle, MD & Chris Hogan, PhD, Medical School
  33. Rapid Deployment of School-Based Mental Health Providers during the COVID-19 Crisis
    PI: Susan M. Mason, PhD, MPH, School of Public Health
  34. Multivalent Vaccine to Provide Sterilizing Immunity Against COVID-19
    PI: Mythili Dileepan, PhD, College of Veterinary Medicine
  35. Assessing Efficacy of a COVID-19 Stress Management Intervention
    PI: Patricia Frazier, PhD, College of Liberal Arts
  36. Real-Time Sequencing and Bioinformatics of SARS-COV2 from Positive Animal Samples at the Minnesota Veterinary Diagnostic Laboratory
    PI: Sunil Mor, PhD, College of Veterinary Medicine
  37. Serum SARS-CoV-2 Neutralization Activity
    PI: Tyler Bold, MD, PhD, Medical School
  38. Structural Basis of Remdesivir Inhibiting SARS-2 Transcription
    PI: Bin Liu, PhD, The Hormel Institute
  39. When Did COVID-19 Emerge in Minnesota? An Analysis of Newborn Saliva Swabs Spanning 11/2019 through 3/2022
    PI: Mark R. Schleiss, MD, Medical School
  40. Role of SARS-CoV-2 N Protein in COVID-19 Disease Pathogenesis
    PI: Qinfeng Huang, PhD, College of Veterinary Medicine
  41. Intubation Box-Generation 2
    PI: Gwenyth Fischer, MD, Medical School
  42. The Development of SARS-CoV-2 Antibody Testing
    Medical School
  43. Low Cost ECMO System
    Medical School
  44. Mouse Model Host for SARS-CoV-2
    PI: Michael Koob, PhD, Medical School
  45. Association of Intestinal Dysbiosis with Clinical Outcomes in COVID-19 Patients
    PI: Alexander Khoruts, MD, Medical School
  46. COVID-19 Assessment with Point-of-Care Ultrasonography (POCUS)
    PI: Matthew Yocum, MD, Medical School
  47. Exploring the Role of RIP140 in Regulating the Acute Inflammatory Response in COVID-19 Patients
    PI: Pat Arndt, MD, Medical School
  48. Understanding Critical Virus-Host Interactions During the Life Cycle of SARS Coronavirus-2
    PI: Anja Bielinsky, PhD, College of Biological Sciences
  49. VIRUS Registry
    PI: Ronald Reilkoff, MD, Medical School
  50. Psychological and Biological Sequelae of COVID-19 in Adolescents with and without Non-Suicidal Self-Injury
    PI: Kathryn Cullen, MD, Medical School
  51. Angiotensin Peptide Turnover and Flux in COVID-19 Pathogenesis
    PI: Peter Crawford, MD, PhD, Medical School
  52. COVID-19 Antibody Testing Among Get Well Loop Participants
    PI: Pita Adam, MD, Medical School
  53. Novel Therapeutic Agents Targeting Replication of COVID-19  
    PI: Da-Qing Yang, PhD, The Hormel Institute
  54. Development of Molecular and Bioinformatic Methods for Pan-Virome Analysis of SARS-COV-2 and Co-Circulating Viruses
    PI: Noelle Noyes, DVM, PhD, College of Veterinary Medicine
  55. Modeling of Virus/Medicine Transport in Respiratory Systems and Their Interactions with Epithelial Cells for COVID-19 Treatment
    PI: Suo Yang, PhD, Institute for Engineering in Medicine
  56. A Platform Targeting Protein Structural Dynamics for High-Throughput Discovery of Small Molecule Antiviral Leads
    PI: Joseph Muretta, College of Biological Sciences
  57. Analysis of Shedding of SARS-CoV-2 RNA in Breast Milk: Is there Risk to Newborns?
    PI: Erin Osterholm, MD, Medical School
  58. Synthesis of GMP grade Apilimod for COVID 19 Clinical Trials
    PI: Ricardo Battaglino, PhD, Medical School
  59. Optimizing a T3 Formulation for COVID-19 Patients With ARDS
    PI: Robert Schumacher, PhD, Center for Translational Medicine
  60. Prevalence Of Sars-Cov-2 Igg Antibodies In Patients With Cystic Fibrosis In The First 6 Months Of Known Virus In The State Of Mn And Monitoring Of Igg Levels In Follow-Up (6 Months & 1 Year)
    PI: Joanne Billings MD, MPH, Medical School
  61. Understanding Protective Antibody Mechanisms in COVID-19 to Engineer Universal Coronavirus Vaccine
    PI: Geoffrey Hart, PhD, Medical School
  62. Use of PDE5 Inhibitor for Preventing Cardiac Damage by SARS-CoV-2 in COVID-19 Patients with Cardiopulmonary Diseases
    PI: Bong Sook Jhun, PhD, Medical School
  63. Impact of COVID-19 on Antimicrobial Use and Antimicrobial Resistance
    PI: Randall Singer, DVM, PhD, College of Veterinary Medicine
  64. Phone or Video (POV) Telemedicine for Opioid Use Disorder
    PI: Cuong Pham, MD, Medical School
  65. Identification of High-Risk COVID-19 Patients Through ACE Gene Polymorphism Detection
    PI: Peter Larsen, PhD, College of Veterinary Medicine
  66. Genomics of COVID-19: A Collaboration with the International COVID Human Genome Effort Consortium
    PIs: Christen Ebens, MD, MPH, and Meghan Rothenberger, MD, Medical School
  67. Development of Microbiome Modulation Strategies to Prevent and Treat Perinatal COVID-19
    PI: Cheryl Gale, MD, Medical School
  68. Uncovering Resilience: Hair as a Retrospective Biomarker of Health and Coping During the COVID-19 Pandemic
    PIs: Alexander Herman, MD, PhD, and David Darrow, MD, MPH, Medical School

Research Stories

University of Minnesota Researchers Address Unique COVID-19 Challenges Through Innovation

Among supply chain challenges, limited numbers of personal protective equipment (PPE) and medical supplies, researchers and students at the University of Minnesota have been thinking up and implementing bold ideas to solve the unique problems presented during COVID-19.

Open-Source Release Allows Coventor to Be Produced Worldwide

The design for a low-cost ventilator created at the University of Minnesota has now been released as open-source, giving manufacturers around the globe a way to help supply care providers during the coronavirus pandemic.

FDA authorizes first-of-its-kind low-cost ventilator developed by University of Minnesota

Known as the Coventor, this ventilator is the first-of-its-kind authorized for use under the FDA's Emergency Use Authorization for the COVID-19 outbreak.

U Researchers Orchestrate State’s Fastest On-Site Testing for COVID-19

Leaders from the University of Minnesota Medical School transformed two research buildings to create the state’s fourth on-site testing facility, now, with the fastest turnaround results in Minnesota.

U of M researchers find key—and vulnerable—features of novel coronavirus

A University of Minnesota team studied how mutations that changed the structure of a SARS-CoV-2 protein enabled it to attach more securely to human cells than its predecessor, infect human cells better, and spread faster.

DIY face masks during COVID-19

While DIY masks are not as effective as surgical or N95 masks* in preventing the spread of COVID-19, some doctors and other health care professionals are wearing them over the top of the higher-tech masks to increase durability.