HTLV-1

Findings by UMN Researchers Could Help Fight Cancer

Interdisciplinary researchers from the Institute for Molecular Virology (IMV) have made a key discovery that could help fight Human T-cell leukemia virus type (HTLV-1).

HTLV-1 is a rare but extremely infectious virus spreading among remote areas of central Australia. The virus produces particles that can then spread to other cells in the body. University of Minnesota researchers, including Louis Mansky, PhD, director of the IMV and professor in the School of Dentistry, and his team, created mutations in HTLV-1’s main structural protein (called Gag) and investigated how these mutants affected the production of HTLV-1 particles.

“By creating these mutants, we found important new insights regarding how the structure of the Gag protein is critically important in making new virus particles,” said Mansky, the lead author of the study.

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